Nipro Brizio Adult Membrane Oxygenator
The Nipro Brizio Adult Membrane Oxygenator is a combined oxygenator and venous reservoir system designed for use in cardiopulmonary bypass procedures during adult cardiac surgery. It performs the critical functions of blood oxygenation, carbon dioxide removal, heat exchange, blood filtration, and volume management in a single integrated unit. This helps simplify the extracorporeal circuit and improves surgical workflow.
Summary
In essence, the Brizio Adult Membrane Oxygenator is a single-use, high-function device that combines:
✔ Efficient oxygenation and CO₂ removal
✔ Blood heat exchange
✔ Filtration of shed blood via cardiotomy filtering
✔ Lower priming and improved blood compatibility
Key Features & Specialized Design
- Integrated Functions
Membrane Oxygenation: Provides efficient gas exchange (O₂ in, CO₂ out) via a hollow-fiber membrane chamber.
Venous Reservoir: A hard-shell blood reservoir stores and manages venous return during bypass.
Cardiotomy Filter: Integrated filtration (≈40 µm mesh) removes microemboli and debris from shed blood before recirculation.
- Performance & Blood Handling
Less priming volume: Reduces the volume of fluid needed to fill the circuit before use, minimizing hemodilution.
Superior gas exchange performance: Supports full cardiopulmonary bypass demands with a high membrane surface area (~2.2 m²).
NIPRO Synthetic Coating E8: Enhances blood compatibility and may reduce inflammatory responses.
Microbubble & GME withdrawal: Designed to allow efficient removal of microbubbles and gaseous microemboli (GMEs), which improves safety.
- Circuit Compatibility
Standard 3/8″ and 1/4″ connection ports for venous inlet/outlets, recirculation, vent lines, and aspirated blood return.
Multiple Luer lock sampling and infusion ports for pressure monitoring, temperature probes, and drug administration.
- Heat Exchange
Integrated heat exchanger: Allows controlled warming or cooling of the blood to maintain targeted patient body temperature during bypass.
- Sterilization & Materials
ETO sterilized (ethylene oxide) for safe surgical use.
Hollow fiber membrane typically made from microporous polypropylene.
- Clinical Utility
The device’s integrated design reduces circuit complexity and lowers priming requirements, which can help minimize the inflammatory response, improve perfusion quality, and support efficient postoperative recovery for adult patients undergoing various open-heart procedures such as coronary artery bypass grafting (CABG), valve repair/replacement, and other cardiothoracic surgeries.
